Metabolism Alprazolam is thoroughly metabolized in people, mostly by cytochrome P450 3A4 (CYP3A4), to 2 significant Lively metabolites in the plasma: four-hydroxyalprazolam and ?-hydroxyalprazolam. The plasma circulation amounts of the two Lively metabolites are fewer than four% in the mother or father. The claimed relative potencies in benzodiazep